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Systemic cryptococcosis is a systemic mycosis acquired by the respiratory route, with the primary focus of infection in the lungs, and with occasional hematogenous dissemination, characteristically to the meninges, and on occasion to skin.


Causes:

Associated with avian feces worldwide (parakeets, budgerigars, canaries, and especially pigeons). C. neoformans is inhaled in dust and causes a primary pulmonary focus of infection with subsequent hematogenous dissemination to meninges, kidneys, and skin. Between 10 and 15% of patients have skin lesions. Cell­mediated immune deficiency is an important factor in pathogenesis in many patients.


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