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Mastocytosis is associated with an abnormal accumulation of mast cells in the skin and at various systemic sites, which, because of pharmacologically active substances, is manifested clinically by local cutaneous and systemic symptoms. A consensus-based classification that divides mastocytosis into four categories.


Causes:

Mast cells contain several pharmacologically active substances that are associated with the clinical findings in mastocytosis: histamine (urticaria, GI symptoms), prostaglandin D2 (flush, cardiovascular symptoms, GI symptoms), heparin (bleeding into lesion at biopsy site), neutral protease/ acid hydrolases (patchy hepatic fibrosis, bone lesions).


Symptoms:

*Hives & other rashes
*Itching, with and without rashes
*Itching, with and without rashes
*Fatigue
*Peripheral neuropathy and paresthesias
*Osteoporosis
*Muscle pain
*Vomiting

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