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Cryoglobulinemia (CG) is the presence of serum immunoglobulin (precipitates at low temperature and redissolves at 37°C) complexed with other immunoglobulins or proteins. Associated clinical findings include purpura in cold-exposed sites, Raynaud's phenomenon, cold urticaria, acral hemorrhagic necrosis, bleeding disorders, vasculitis, arthralgia, neurologic manifestations, hepatosplenomegaly, and glomerulonephritis.


Precipitation of cryoglobulins (when present in large amounts) causes vessel occlusion, also associated with hyperviscosity (type I); immune complex deposition followed by complement activation and inflammation; platelet aggregation/consumption of clotting factors by cryoglobulins, causing coagulation disorder; small vessel thromboses and vasculitis produced by immune complexes (types II and III).


* Purple/red spots on the extremities
* Skin ulcers and gangrene
* Fever
* Weakness
* Numbness, tingling, or weakness in the hands or feet
* Weight loss

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