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Gangrenous cellulitis (infectious gangrene) is characterized by rapid progression of infection with extensive necrosis of subcutaneous tissues and overlying skin. Several clinical types of gangrenous cellulitis occur dependent on the causative organism, the anatomic location of the infection, and predisposing conditions. Several subtypes of necrotizing fasciitis are recognized. Correct diagnosis is imperative in understanding pathogenesis and deciding on the appropriate antimicrobial and surgical therapies.


Gangrene is necrosis and subsequent decay of body tissues caused by infection or thrombosis or lack of blood flow. It is usually the result of critically insufficient blood supply sometimes caused by injury and subsequent contamination with bacteria. This condition is most common in the extremities.

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