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A dermatofibroma is a common benign fibrous skin lesion.

A dermatofibroma is also sometimes called a fibrous histiocytoma. It is due to a non-cancerous growth of dermal dendritic histiocyte cells. In some cases it arises at the site of a minor injury, especially an insect bite or thorn prick. The cause is unknown; whether it is due to a neoplasm or reactive process is debated.

Dermatofibromas most often occur on the legs and arms. Once developed, they usually persist for years. They appear as firm-feeling nodules, often yellow-brown in colour, sometimes pink and sometimes quite dark, especially in dark coloured skin. If the skin over a dermatofibroma is squeezed a dimple forms, indicating tethering of the skin to the underlying fibrous tissue.

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