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Flegel disease is also known as ‘hyperkeratosis lenticularis perstans'. It was first described by Flegel in 1958. It is characterised by red-brown papules with irregular horny scales located mainly on the top surface of the feet and lower legs. It is very similar to Kyrle disease and has been regarded as a variant of Kyrle's, however its clinical and pathological picture is sufficiently different to make it its own disease entity.


The cause of the disease is unknown. It is thought to be an inherited condition although cases have been reported where there is no family history of the disease. Exposure to the sun has also been implicated but not proven.

Flegel disease has been reported to rarely affect some families that were also prone to skin and gastrointestinal cancers.


Lesions are small, red-brown, 1-5mm scaly papules that appear most commonly on the top surface of the feet and lower legs. Removal of the scale reveals a bright red base, often with pinpoint bleeding. In rare instances, the outer ear lobes, arms, palms, soles, and oral mucosa may be affected. Lesions are not usually painful.

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